Everything About Difference between Avanafil vs tadalafil vs Sildenafil
Sexual problems like erectile dysfunction (ED) or impotence, low testosterone levels, premature ejaculation (PE), etc.; are more common than they are talked about. The social taboos hold back most men from getting the right treatment at the right time. Thanks to medications like Avanafil, Tadalafil, Sildenafil, etc.; these sensitive medical conditions are perfectly curable. But which one to pick? Which one is stronger? For the time being, let us have a comparative study of Avanafil, Tadalafil, and Sildenafil.
What is Avanafil?Â
Avanafil is a generic pharmaceutical drug that has gained much popularity as an effective medication for erectile dysfunction. This drug has been found to have significant selectivity of phosphodiesterase type 5 and a higher selectivity against phosphodiesterase type 1 and phosphodiesterase type 6.
What is Sildenafil?Â
Sildenafil is also a popular drug to fight out erectile dysfunction. It acts by inhibiting cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). It boosts up the blood vessels and greater blood circulation to particular areas of the body.
What is Tadalafil?Â
Tadalafil is quite a popular medication for curing erectile dysfunction in men. It happens to be a phosphodiesterase type 5 inhibitor (PDE5 inhibitor) i,e vasodilatation pharmaceutical drug.
Avanafil vs Tadalafil vs Sildenafil: Key Differences ExplainedÂ
| Parameters | Avanafil | Sildenafil | Tadalafil |
| Nature of Salt | phosphodiesterase type 5 inhibitor, | phosphodiesterase type 5 (PDE5) | phosphodiesterase type 5 inhibitor, |
| Erection Duration | 6 to 7 hours | 4 hours | 17 to18 hours |
| Mechanism of Action | Works by inhibiting the effect of PDE5. This inhibition leads to penile erection due to the inflow of blood into the area. | Sildenafil has no direct relaxant effect on isolated human corpus cavernosum, but increases the effect of nitric oxide by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for the degradation of cGMP in the corpus cavernosum. When sexual stimulation causes the local release of Nitric Oxide, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in effortless muscle relaxation and increased flow of blood to the corpus cavernosum. Sildenafil has no effect in the absence of sexual stimulation. | Works by inhibiting the effect of PDE5. This inhibition leads to penile erection due to the inflow of blood into the area. |
| Dosage strengths available | 50 mg /100 mg /200 mg | 25 mg /50 mg /75 mg /100 mg | 2.5 mg, 5 mg, 10 mg, and 20 mg |
| Timing of Consumption | 30 minutes prior to the sexual act | 30 to 60 minutes prior to the sexual act | 30 minutes before the sexual act |
| Dissolution duration | 45 minutes | 45 minutes | 30 minutes |
| Side effects | The most commonly documented adverse reactions include back pain, nasal congestion, headache, flushing, and nasopharyngitis | Side effects by this drug are usually on placebo respiratory tract infection, back pain, flu syndrome, and arthralgia. In fixed-dose studies, dyspepsia (17%) and abnormal vision (11%) were more common at 100 mg than at lower doses. | The most common potential adverse effect of using tadalafil are backpain, burping acid reflux, headache, stomach discomfort or pain, indigestion, muscle aches, flushing, and stuffy and runny nose. |
| Storage requirement | 20°C – 25°C | 20°C – 25°C | 20°C – 25°C |
Avanafil vs Tadalafil vs Sildenafil: Which one is Best?
All the three medications are phosphodiesterase type 5 inhibitors, and have got their respective pros and cons. But so far having a longer duration of penile erection is concerned, Tadalafil clearly wins the game way ahead of Avanafil and Sildenafil.Â
All of these three medications are FDA-approved and safe medicaions to address symptoms of erectile dysfunction or impotence in men. Yet, neither of them should be taken without medical consultation otherwise they might inflict side effects.Â
Sildenafil, Avanafil and Tadalafil happen to be strong prescribed medications that can cause serious side effects if consumed without a thorough medical consultation. Hence a detailed diagnosis is advised before finalising either of these two pharmaceutical drugs to cure erectile dysfunction.