Avanafil happens to be quite a magical pill when it comes to treating sexual problems like erectile dysfunction or ED among men. Let us see how long it takes to come into action and how long the effects of Avanafil last.
Important Details about Avanafil Drug for ED
- Avanafil is an FDA-approved branded pharmaceutical medication for vasodilation.
- It is somewhat white crystalline powder in appearance.
- Avanafil is found to have significant selectivity for phosphodiesterase type 5 and a higher selectivity against phosphodiesterase type 1 and phosphodiesterase type 6.
- It is used to treat penile erection problems in men, or what is commonly termed as erectile dysfunction (ED) or impotence.
How long does Avanafil take to work?
This medication needs to be consumed some 30 minutes before the sexual act to have a desirable penial erection.
| Avanafil Dosage Strengths | Time it takes to work |
| Avanafil 50 mg | Minimum 30 minutes (approx.) |
| Avanafil 100 mg | Minimum 30 minutes (approx.) |
| Avanafil 200 mg | Minimum 30 minutes (approx.) |
Avanafil is quite an advantageous medication as it has a very fast onset of action, as compared to that of the other PDE5 inhibitors. It is absorbed quickly, reaching a maximum serum concentration in about thirty to forty-five minutes.
How long does Avanafil last?
Avanafil is quite a popular choice for getting a penial erection. It is capable of producing a penial erection of six to seven hours duration.
How Long Does Avanafil Stay in the Body?
Avanafil usually starts to get excreted out of a male body between six to seventeen hours of its ingestion. Following its oral ingestion, Avanafil is extensively metabolized. Approximately 62% of a given dose is excreted as metabolites in the feces and approximately 21% as metabolites in the urine.
What are the factors that help Avanafil results last longer?
- A healthy and balanced diet
- Enough daily exercises
- Zero alcohol
- No Smoking
- No substance abuse
- Reduced mental stress
How does Avanafil work?
As a phosphodiesterase (PDE) type 5 inhibitor, avanafil is responsible for blocking the phosphodiesterase enzyme, preventing the degradation of cGMP. The increased levels of cGMP induce vasodilation, thereby stimulating an increased blood flow in the penial area.
As PDE5 inhibitors require the endogenous release of nitric oxide in order to exert their pharmacologic effect, Avanafil will have no effect on the consumer in the absence of sexual stimulation. Avanafil’s mechanism of action sets off only once the nitric oxide is released, on getting some sort of sexual stimulation.
In the simplest terms, on getting the sexual stimulation, Avanafil works by relaxing and widening of the blood vessels present in the lungs, which allows a seamless and increased blood flow throughout the body; which again pushes enough blood to the penis for a strong erection, for intercourse and enough sexual pleasure.
What to avoid when taking Avanafil?
The effect of Avanafil in combination with any organic nitrate is contraindicated. In a life-threatening situation, nitrate medication can only be administered at least 12 hours after the last dose of avanafil was administered. Also, utmost caution must be taken when using Avanafil concomitantly with alpha-blocker medications and antihypertensive medications.
The use of alcohol along with avanafil is not recommended due to the increased potentiation of Blood Pressure lowering effects leading to orthostatic hypotension, headache, and dizziness.
Apart from these, one should also avoid high-fat content foods that slow down the efficacy of Avanafil tablets.