How long does it take Fildena to work and How long does it last?
Fildena is one of the most commonly prescribed medications by physicians when it comes to treating sexual problems like erectile dysfunction (ED) or impotence among men. Let us see how long it takes to come into action and how long the effects of Fildena last.
Important Details about Fildena Drug for ED
- Fildena is an FDA-approved branded pharmaceutical medication.
- Based on the salt of Sildenafil Citrate, which is a phosphodiesterase type 5 (PDE5) inhibitor, Fildena is a vasodilation drug.
- It is primarily used to treat erection issues in men, as it is capable of producing a penial erection for about four to five hours duration.
- Additionally, it is also used in treating NYHA Functional Class II-III Pulmonary Arterial Hypertension and Premature Ejaculation
How Long Does it Take for Fildena to Work?
Fildena is quite an advantageous and effective medication. This medication can be consumed some 30 to 60 minutes before the sexual act to have the desired penial erection, for proper intercourse and optimum sexual pleasure.
| Fildena Dosage Strengths | Time takes to work |
| Fildena 25 mg | 30 minutes to 60 minutes (approx) |
| Fildena 50 mg | 30 minutes to one hour (approx) |
| Fildena 100 mg | At max 1 hour (approx) |
| Fildena 150 mg | 30 minutes to one hour (approx) |
How Long Does Fildena Last?
Fildena is quite a popular choice when it comes to achieving and maintaining a strong penial erection. It is capable of demonstrating its results for up to about 4 to 5 hours duration.
How Long Does Fildena Stay in the System?
Below lies an approximate timeline that is followed by Fildena once it is ingested by a patient.
- Post 12 minutes of taking Fildena: Some men can achieve an erection as quickly as in 12 minutes of taking a Fildena tablet.
- Post 27 minutes: Most men experience the best of Fildena (Sildenafil) after 27 minutes.
- Post 57 minutes: After 1 hour, the maximum concentration of the drug is in the bloodstream (this may increase by another hour if a meal was taken prior to taking the medication).
- Post 4 hours: Fildena (Sildenafil) has a 4-hour ‘half-life’, meaning half of the drug has left the bloodstream after 4 hours.
- Post 10 hours: Very few men (in rare cases) may still be able to achieve an erection after 10 hours, although the duration will become shorter.
- Post 24 hours: After 24 hours all traces of the drug in the bloodstream have practically gone.
What are the Factors that Help Fildena Effect Last Longer?
- A healthy and balanced diet
- Enough daily exercises
- Zero alcohol
- No Smoking
- No substance abuse
- Reduced mental stress
How Does Fildena Work?
The salt of Sildenafil Citrate, present in any Fildena tablet, is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum, where PDE5 is responsible for the degradation of cGMP.
It is important to note here that Sildenafil Citrate itself does not have any direct relaxant effect on isolated human corpus cavernosum but somehow boosts the relaxant effect of nitric oxide (NO) on this tissue.
When the NO/cGMP pathway is activated, as occurs with sexual stimulation, inhibition of PDE5 by Sildenafil Citrate results in increased levels of cGMP in the corpus cavernosum. Therefore sexual stimulation is required in order for sildenafil to bring out its effects.
In the simplest terms, Sildenafil works by relaxing and widening the blood vessels present in the lungs, which allows a seamless and increased blood flow throughout the body. This eventually pushes enough blood to the penis for a strong erection that is necessary for intercourse, and enough sexual pleasure.
It should be noted here that things like high-fat content meals and alcohol can bring down the efficacy of this drug. Hence such items should be avoided with Fildena in order to get the best results. Additionally, there are a few medications that interact adversely with Fildena, as mentioned below, and hence should be avoided.
Other Drug Interactions: Drugs to Avoid taking with Fildena
- Medications based on nitrates, such as isosorbide mononitrate (Monoket) and nitroglycerin (Nitrostat)
- Blood pressure drugs, such as calcium channel blockers, or alpha-blockers
- Certain pulmonary hypertension drugs, such as riociguat (Adempas)
- Protease inhibitors, a class of HIV medications
- Antifungal drugs, such as ketoconazole and itraconazole (Onmel, Sporanox)
- Antibacterial drugs, such as clarithromycin (Biaxin)
- Anticoagulants
- Antihistamines
- Benzodiazepines
- Cardioselective beta blockers
- Corticosteroids
- Gamma-aminobutyric acid analogs
- Omega-3 polyunsaturated fatty acid
- Miscellaneous analgesics
- Nonsteroidal Antiinflammatory Drugs (NSAIDs)
- PDE5 inhibitors
- Statins
- Stimulants
- Selective Serotonin and Norepinephrine Reuptake Inhibitors (SSNRIs)
- Vitamins- B12, C & D
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