Everything about Sildenafil: How Long it takes to Work & How Long it Lasts?
Among the many health issues exclusive only to men, certain sexual problems are quite common, between 18 to 70 years of age. The scope of usual sexual incidents in males consists of four aspects, namely, sexual desire, erection, ejaculation and detumescence, i,e penile flaccidity. Erectile dysfunction or ED, and premature ejaculation or PE, are two of the most commonly found medical conditions that cause much problems to men across the world.
What is Sildenafil Citrate?
Sildenafil or Sildenafil Citrate is quite a popular selective phosphodiesterase type 5 inhibitor (PDE5 inhibitor) i,e vasodilatation pharmaceutical drug. It acts by inhibiting cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).
In simplest of terms, it opens up the blood vessels and allows greater blood circulation to the penile area in male bodies, causing a desired penile erection for decent intercourse and optimum sexual pleasure. It happens to be one of the most commonly prescribed medications for treating symptoms of ED.
What is the ideal or correct dosage of Sildenafil?
The recommended initial dose of Sildenafil to cure ED symptoms in men, is 5mg or 20 mg orally three times a day, about 4 to 6 hours apart. It can be taken about 30 to 60 minutes before the sexual act. Based upon its effectiveness and tolerability, the dose can be increased or decreased; but strictly as per a doctor’s guidance.
How does Sildenafil Citrate work?
Sildenafil has no direct relaxant effect on isolated human corpus cavernosum but increases the effect of nitric oxide by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for the degradation of cGMP in the corpus cavernosum. When sexual stimulation causes the local release of Nitric Oxide, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in effortless muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil has no effect in the absence of sexual stimulation.
How long does it take for Sildenafil to work or to kick in?
Sildenafil is quite an advantageous medication when it comes to getting a penile erection. This medication can be consumed some 30 to 60 minutes before the sexual act in order to have a desirable penial erection.
When it comes to observing the onset time of erections after sildenafil (50 mg) or placebo dosing following some visual sexual stimulation (VSS), it can be said that less than 60% penile rigidity is achieved in 70 minutes. The duration of ‘hard enough for penetration’, and ‘fully hard erections’, is at 2 and 4 hours respectively, after sildenafil (100 mg) or placebo dosing. However, alcohol and high-fat content meals should be avoided while consuming this medication; as they can slow down its effects.
How long will Sildenafil last?
Sildenafil is quite a popular choice for getting a penial erection. It is capable of demonstrating its results up to 4 to 6 hours duration, at maximum.
Sildenafil or Sildenafil Citrate is an FDA-approved medication against erectile dysfunction in men. It has already been tried by millions of men worldwide, and has generated great results for patients.
Yet one should always go for a thorough diagnosis by an authorised medical practitioner before consuming this medication, as it may react differently for different people. Further, it might inflict different side effects in some, and it might also react adversely with some of the existing medications. Hence people should have proper medical consultation to understand the suitability of the drug for them.