how long does it take tadalafil to work

Tadalafil is the strongest medication of all the options available to treat the sexual problem of erectile dysfunction (ED) or impotence in men; a condition in which men find it extremely difficult to attain and maintain a strong penile erection, in order to meet intercourse and sufficient sexual pleasure. 

Important Things to Note about Tadalafil Drug for ED

  • Tadalafil is an FDA-approved branded pharmaceutical medication for vasodilation. 
  • It belongs to the class of phosphodiesterase type 5 (PDE5) inhibitors. 
  • This medication is associated with the treatments of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy (BPH). It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. 
  • It is capable of offering penile erections up to as high as 36 hours approximately, which is why it is also called the ‘weekend pill’. 

How do Tadalafil Tablets work?

PDE5 inhibitors, like Tadalafil, work by increasing blood flow toward the penis. They block a specific enzyme in the blood vessels. It relaxes the blood vessels, resulting in an increased blood flow toward the penile area in order to produce a desirable erection for proper intercourse and pleasurable sexual act.  

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4 tablets in 1 strip
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How Long Does it Take for Tadalafil to Work?

This medication can be consumed some 30 minutes before the sexual act to have a desirable penial erection. 

Tadalafil Dosage Strengths  Time it takes to work
Tadalafil 10 mg Minimum 30 minutes 
Tadalafil 20 mg Minimum 30 minutes
Tadalafil 40 mg Minimum 30 minutes 
Tadalafil 60 mg Minimum 30 minutes 

How Long Does Tadalafil Stay in the System?

This medication gets completely excreted out of a male body only after 2 days. It is excreted predominantly as metabolites, mainly in the feces (roughly about 61% of the dose) and to a lesser extent in the urine (roughly about 36% of the dose).

How should Tadalafil doses be taken for the best results? 

In case a patient is taking generic Tadalafil tablets or any of its branded tablets like Cialis, Tadarise, etc, in order to get a desired erection, the medication needs to be taken about 30 minutes prior to the sexual act. 

However, if a patient is having Tadalafil for addressing issues like BPH or PAH, ideally he should maintain a fixed time for each day. This becomes helpful in maintaining a fixed or steady level of Tadalafil in the body. The factors that help Tadalafil last longer are as follows:  

  • A healthy and balanced diet
  • Enough daily exercises 
  • Zero alcohol
  • No Smoking 
  • No substance abuse 
  • Reduced mental stress

What to avoid consuming when taking Tadalafil? 

  • High Fat Content Meals
  • Alcohol 
  • Receiving treatments involving forms of nitrates, such as isosorbide mononitrate (Monoket) and nitroglycerin (Nitrostat)
  • Taking blood pressure drugs, such as calcium channel blockers or alpha-blockers, which can also treat an enlarged prostate
  • Certain pulmonary hypertension drugs, such as riociguat (Adempas)
  • Protease inhibitors, a class of HIV medications
  • Antifungal drugs, such as ketoconazole and itraconazole (Onmel, Sporanox)
  • Antibacterial drugs, such as clarithromycin (Biaxin)

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