Difference between Sildenafil and Tadalafil: Everything Explained

Sildenafil vs tadalafil

Millions of men, aged between 19 to 60 years, complain about some problems pertaining to penile erection. Erectile dysfunction is more common than what the reported counts say. Fortunately, there are some really effective medications available in the market like Sildenafil, Tadalafil, etc; to combat such medical conditions.

Vidalista 60 MG

Free shipping on all orders over $199
Tadalafil
$115.00$345.00

Fildena 100 mg

Free shipping on all orders over $199
Sildenafil
$80.00$236.00

Malegra 200 mg

Free shipping on all orders over $199
Sildenafil
$115.00$310.00

Tadarise 60 mg

Free shipping on all orders over $199
Tadalafil
$125.00$355.00

Cenforce 120 mg

Free shipping on all orders over $199
Sildenafil
$82.00$246.00

Vidalista 60 MG

Free shipping on all orders over $199
Tadalafil
$115.00$345.00

Fildena 100 mg

Free shipping on all orders over $199
Sildenafil
$80.00$236.00

Malegra 200 mg

Free shipping on all orders over $199
Sildenafil
$115.00$310.00

Tadarise 60 mg

Free shipping on all orders over $199
Tadalafil
$125.00$355.00

Cenforce 120 mg

Free shipping on all orders over $199
Sildenafil
$82.00$246.00

What is sildenafil? 

Sildenafil is also a popular drug to fight out erectile dysfunction. It acts by inhibiting cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). It boosts up the blood vessels and greater blood circulation to particular areas of the body. Viagra happens to be one of the most well-known branded drugs, as a form of avanafil.  

What is tadalafil? 

Tadalafil is quite a popular medication for curing erectile dysfunction in men. It happens to be a phosphodiesterase type 5 inhibitor (PDE5 inhibitor) i.,e vasodilatation pharmaceutical drug. 

Tadalafil vs Sildenafil: Key Differences Explained 

Parameters Tadalafil  Sildenafil
Nature of Salt phosphodiesterase type 5 inhibitor, phosphodiesterase type 5 (PDE5)
Erection Duration 17 to18 hours 4 hours
Mechanism of Action  Works by inhibiting the effect of PDE5. This inhibition leads to penile erection due to the inflow of blood into the area. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum, but increases the effect of nitric oxide by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for the degradation of cGMP in the corpus cavernosum. When sexual stimulation causes the local release of Nitric Oxide, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in effortless muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil has no effect in the absence of sexual stimulation.
Dosage strengths available 2.5 mg, 5 mg, 10 mg, and 20 mg 25 mg /50 mg /75 mg /100 mg
Timing of Consumption 30 minutes before the sexual act 30 to 60 minutes prior to the sexual act or intercourse
Dissolution duration 30 minutes 45 minutes
Side effects The most common potential adverse effect of using tadalafil are backpain, burping acid reflux, headache, stomach discomfort or pain, indigestion, muscle aches, flushing, and stuffy and runny nose.  Side effects by this drug are usually on placebo respiratory tract infection, back pain, flu syndrome, and arthralgia. In fixed-dose studies, dyspepsia (17%) and abnormal vision (11%) were more common at 100 mg than at lower doses.
Storage requirement 20°C – 25°C 20°C – 25°C

Other Drug Interactions – Sildenafil vs Tadalafil  

Both of these salts are phosphodiesterase type 5 (PDE5) inhibitors, and have similar interactions with other drugs. Hence the following drugs should be avoided while receiving a treatment involving either of these two drugs:

  • Various forms of nitrates, such as isosorbide mononitrate (Monoket) and nitroglycerin (Nitrostat)
  • certain blood pressure drugs, such as calcium channel blockers
  • alpha-blockers, which can treat high blood pressure or an enlarged prostate
  • certain pulmonary hypertension drugs, such as riociguat (Adempas)
  • protease inhibitors, a class of HIV medications
  • antifungal drugs, such as ketoconazole and itraconazole (Onmel, Sporanox)
  • antibacterial drugs, such as clarithromycin (Biaxin)

Sildenafil or Tadalafil: Which one is better?

Both of Sildenafil and Tadalafil are phosphodiesterase type 5 inhibitors, who work in similar mechanism. However, both of them differ in terms of erection duration. Tadalafil here clearly wins the game way ahead of Sildenafil; with its longer erection projecting capacity. 

But then again different patients react to these two different drugs in quite unique ways. Hence it is advised to only go with proper medical consultation from an authorized medical practitioner, before finalizing on any of these two drugs. The slightest of irresponsibility can cause much dreadful consequences to one.

Other related Medicines:

FAQs About the Differences between Sildenafil and Tadalafil

Out of Sildenafil and Tadalafil, which one is stronger?

Tadalafil is much stronger than Sildenafil, which is capable of offering a much longer erection duration.

Do Sildenafil and Tadalafil have the same purpose or work?

Both of the medicines belong to the same class of drug, i,e PDE5 inhibitor and has the same kind of mechanism of work for the same set of purpose. Yet they are two different pharmaceutical ingredients and project different intensity in the results, and have different interactions with other drugs.

Which one is safer: Sildenafil or Tadalafil?

Both of these are FDA approved medications to eradicate erectile dysfunction from men. Moreover, by now, various patients across the globe have already tried either of them, and have experienced positive results. Hence both are safe as pharmaceutical drugs. Yet, neither of them should be taken without medical consultation otherwise they might inflict side effects.

Can Sildenafil and Tadalafil be taken OTC or doctor consultation required?

Both Sildenafil and Tadalafil are strong prescribed medications that can cause serious side effects if consumed without a thorough medical consultation. Hence a detailed diagnosis is advised before finalizing either of these two pharmaceutical drugs to cure erectile dysfunction.

Is Tadalafil and Sildenafil available online?

Yes, you may buy this drugs online via our website Alldayplus.