Difference between Sildenafil vs Vardenafil Explained
Erectile dysfunction problems are more prevalent than what gets officially reported, which means still now there are men who are shying away from proper medical diagnosis and not taking the right kind of medication. Thanks to medications like Sildenafil, Vardenafil, and similar ones, erectile dysfunction is completely curable these days.
What is Sildenafil?
Sildenafil is also a popular drug to fight out erectile dysfunction. It acts by inhibiting cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). It boosts up the blood vessels and greater blood circulation to particular areas of the body. Viagra happens to be one of the most well-known branded drugs, as a form of avanafil.
What is Vardenafil?
Vardenafil is a phosphodiesterase (PDE-5) inhibitor, that is used to cure erectile dysfunction by increasing the blood flow towards the penile area by relaxing the muscles in penile blood vessels. However, sexual stimuli is required in order to induce the erection.
Key Differences between Sildenafil vs Vardenafil Explained
|Nature of Salt||phosphodiesterase type 5 inhibitor,||phosphodiesterase type 5 (PDE5)|
|Erection Duration||4 hours||8 hours|
|Mechanism of Action||Sildenafil has no direct relaxant effect on isolated human corpus cavernosum, but increases the effect of nitric oxide by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for the degradation of cGMP in the corpus cavernosum. When sexual stimulation causes the local release of Nitric Oxide, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in effortless muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil has no effect in the absence of sexual stimulation.||Being a phosphodiesterase (PDE) inhibitor, it works by increasing blood flow to the penis; on receiving a sexual stimulation.|
|Dosage strengths available||25 mg /50 mg /100 mg /150 mg / 200 mg||10 mg/ 20 mg/40 mg/ 60 mg|
|Timing of Consumption||30 to 60 minutes prior to the sexual intercourse||25 to 60 minutes before sex prior sex|
|Side effects||Side effects by this drug are usually on placebo respiratory tract infection, back pain, flu syndrome, and arthralgia. In fixed-dose studies, dyspepsia (17%) and abnormal vision (11%) were more common at 100 mg than at lower doses.||Headache, Flushing (reddening of the face, ears, neck and trunk), Dizziness, Back pain, Nausea, Nasal congestion (stuffy nose), Dyspepsia, Sinus inflammation, Flu-like symptoms, Increased creatine level in blood.|
|Storage requirement||20°C – 25°C||15° to 30°C|
Which one is better: Sildenafil or Vardenafil?
Both of Sildenafil and Vardenafil are phosphodiesterase type 5 inhibitors, which work in similar mechanism. So far erection duration is concerned; Vardenafil is a bit ahead of Sildenafil with a capacity of 8 hours, while the former offers 4 hours.
Other Drug Interactions – Sildenafil and Vardenafil
Both of these are PDE5 inhibitors and have similar interactions with other drugs. Hence the following drugs should be avoided while receiving a treatment involving either of these two drugs:
- Various forms of nitrates, such as isosorbide mononitrate (Monoket) and nitroglycerin (Nitrostat)
- Certain blood pressure drugs, such as calcium channel blockers
- Alpha-blockers, which can treat high blood pressure or an enlarged prostate
- Certain pulmonary hypertension drugs, such as riociguat (Adempas)
- Protease inhibitors, a class of HIV medications
- Antifungal drugs, such as ketoconazole and itraconazole (Onmel, Sporanox)
- Antibacterial drugs, such as clarithromycin (Biaxin)
FAQs about the Difference between Sildenafil and Vardenafil
Is Vardenafil or Sildenafil addictive?
Currently, there is no scientific evidence that vardenafil, sildenafil or any other medications used to treat erectile dysfunction are physically addictive.
Is it safe to take Vardenafil 60 mg in the long run?
A 60 mg Vardenafil tablet might be an ideal dose for one patient but then it might be an overdose for another. So, although Vardenafil is already been tried by millions of patients by now, it is always advised to refer to an authorized medical practitioner for guidance about its dosage strengths.
Is Vardenafil approved by the FDA?
Yes, Vardenafil is an FDA-approved drug to cure erectile dysfunction.
Which one is safer: Sildenafil or Vardenafil?
Both of these are FDA-approved medications to eradicate erectile dysfunction in men. Moreover, now, various patients across the globe have already tried either of them, and have experienced positive results. Hence both are safe as pharmaceutical drugs. Yet, neither of them should be taken without medical consultation otherwise they might inflict some serious side effects.